' 
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Caplets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
1%¹
Dietary Fiber
1 g
4%¹
Selenium (from culture media)
100 mcg
182%
RM-10 Fermented Organic Mushroom BlendMaitake (Grifola frondosa) mycelia*, Shiitake (Lentinula edodes) mycelia*, Reishi (Ganoderma lucidum) mycelia*, Coriolus versicolor mycelia*, Bionectria ochroleuca mycelia, Wolfiporia cocos mycelia*, Hericium erinaceus mycelia*, Formitopsis cajanderi mycelia*, Annulohypoxylon stygium mycelia*, Agaricus blazei mycelia*
1.16 g
+
Cat's Claw (Uncaria tomentosa) Bark
240 mg
+
Top Medical Research Studies
8
Selenium nanoparticles show promise
Intracellular Fate of Sub-Toxic Concentration of Functionalized Selenium Nanoparticles in Aggressive Prostate Cancer Cells.
Direct relevance to prostate cancer
We explored the impact of selenium nanoparticles, known for their potential anti-cancer properties, on aggressive prostate cancer cells, specifically the PC-3 line. The study focused on understanding how sub-toxic levels of selenium functionalized nanoparticles affect cell proliferation and their intracellular behavior.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
By utilizing advanced imaging techniques and careful cryopreparation, we aimed to preserve the integrity of the cancer cells while analyzing the distribution of these nanoparticles within them. Our findings revealed that nanoparticles coated with bovine serum albumin (BSA) reduced the migration capability of the cancer cells more effectively than those coated with chitosan.
This difference may be attributed to the BSA coating's ability to prevent harmful interactions with the cell membranes, which in turn limits the generation of reactive oxygen species that can damage cells. Most intriguingly, we observed that these selenium nanoparticles localized in both the mitochondria and lysosome-related organelles within the cells. The presence of nanoparticles in the mitochondria might explain the significant reduction in the PC-3 cells' ability to proliferate.
Overall, our investigation highlights the promising role selenium nanoparticles can play in cancer treatment strategies, providing valuable insights for further research into their cytotoxic mechanisms against prostate cancer.
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8
Selenium’s role in prostate cancer
Response surface methodology optimizes selenium inhibition of prostate cancer PC-3 cell viability.
Direct focus on selenium treatment
Our study focused on understanding how various forms of selenium can impact prostate cancer, specifically the PC-3 cell line. We utilized a systematic approach called Mixture Design Response Surface Methodology to find the most effective combinations of selenium compounds, including sodium selenite, methylseleninic acid, and nano-selenium.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
We began by testing each selenium compound individually to determine their effectiveness at reducing cancer cell viability. Interestingly, we found that the 50:50 mixture of methylseleninic acid and sodium selenite yielded the best results, showcasing impressive antineoplastic potential. However, the combination of nano-selenium with selenite did not demonstrate any additional benefits, suggesting that they might work through similar mechanisms.
This study underscores the importance of recognizing the distinct effects of different selenium compounds when considering them as treatments for prostate cancer. Our findings encourage further research in this area, as the choice and combination of selenium forms could significantly influence treatment outcomes. Overall, selenium shows promise as a potential weapon in the fight against prostate cancer, but we need to keep exploring the variations of these compounds to fully understand their capabilities.
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8
Selenium compounds show anticancer promise
Novel Acylselenourea Derivatives: Dual Molecules with Anticancer and Radical Scavenging Activity.
Direct focus on prostate cancer
We explored how selenium-containing compounds impact prostate cancer, particularly focusing on their potential as both anticancer agents and radical scavengers. In our study, we synthesized a new type of molecule called acylselenourea derivatives, based on structures similar to those found in natural products.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
Through various tests, we evaluated these compounds for their ability to fight cancer cells in prostate, colon, lung, and breast cancers, as well as their effectiveness in scavenging free radicals that can damage cells. The results were promising, revealing that some of these new selenium compounds demonstrated strong anticancer activity by inducing cell death through a process known as apoptosis.
Additionally, they showed radical scavenging capability that performed comparably to well-known antioxidants like ascorbic acid and trolox. This suggests that introducing selenium into these small molecules could yield dual benefits, paving the way for future developments in cancer treatment approaches.
Overall, our findings highlight the exciting potential of selenium derivatives in treating prostate cancer and the importance of continued research in this area.
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Most Useful Reviews
8.8
Cancer reduction
Essential. Since I started taking this supplement a few years ago, I no longer contract colds and flu. This supplement contains 100 mcg of Selenium per dosage (2 pills). Selenium could be beneficial, but it’s crucial not to overdose. A study showed that daily 200 micrograms of selenium reduced cancer occurrences by 42% among older participants compared to a placebo. Selenium users also had up to 63% fewer prostate cancers.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.5
- All Researches
9.5
Selenium/Zinc and Prostate Cancer
Correlation between Selenium and Zinc Levels and Survival among Prostate Cancer Patients.
Examined nutrient impact on survival
We aimed to explore how selenium (Se) and zinc (Zn) levels affect the survival of men diagnosed with prostate cancer. In a study conducted in Poland from 2009 to 2015, we enrolled 338 prostate cancer patients and measured their serum levels of these micronutrients before they started any treatment.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
By categorizing participants into quartiles based on their Se and Zn levels, we utilized Cox regression to evaluate the relationship between these levels and patient survival. Our findings revealed a notable interaction between selenium and zinc, suggesting that higher combined levels of these micronutrients correlate with increased survival rates in prostate cancer patients.
Specifically, patients in the highest quartile of both Se and Zn showed a remarkably high hazard ratio (HR = 20.9) compared to those in the lowest quartile. However, it’s important to note that while the interaction is significant, our study does not isolate the effects of selenium from zinc alone. Therefore, further research is warranted to better understand optimal selenium and zinc levels for different populations and how they might contribute to prostate cancer outcomes.
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9.5
Maitake mushroom shows antitumor effects
Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide).
Study highlights treatment potential
We explored the potential of beta-glucan, a polysaccharide derived from the Maitake mushroom, as a treatment option for hormone-refractory prostate cancer. By treating human prostate cancer PC-3 cells with various concentrations of a highly purified beta-glucan preparation known as Grifron-D (GD), we aimed to understand its antitumor effects.
Our findings were compelling. Within just 24 hours, we observed that concentrations of 480 micrograms/mL of GD led to over 95% cell death. Interestingly, even lower doses, when combined with vitamin C, achieved similar results, effectively inducing over 90% cell death.
We also examined how GD interacted with other anticancer drugs and found a notable synergy with carmustine, which resulted in an approximately 90% reduction in cell survival. The mechanism behind these effects appeared to involve oxidative stress, as indicated by elevated levels of lipid peroxidation and positive staining in our hybridization tests, implying that GD damages cancer cell membranes and triggers apoptosis.
This study suggests that beta-glucan from Maitake mushrooms has significant cytotoxic properties against prostate cancer cells. Its ability to enhance the effects of vitamin C and other treatments offers promising implications for alternative therapeutic strategies in cancer care.
Our findings were compelling. Within just 24 hours, we observed that concentrations of 480 micrograms/mL of GD led to over 95% cell death. Interestingly, even lower doses, when combined with vitamin C, achieved similar results, effectively inducing over 90% cell death.
We also examined how GD interacted with other anticancer drugs and found a notable synergy with carmustine, which resulted in an approximately 90% reduction in cell survival. The mechanism behind these effects appeared to involve oxidative stress, as indicated by elevated levels of lipid peroxidation and positive staining in our hybridization tests, implying that GD damages cancer cell membranes and triggers apoptosis.
This study suggests that beta-glucan from Maitake mushrooms has significant cytotoxic properties against prostate cancer cells. Its ability to enhance the effects of vitamin C and other treatments offers promising implications for alternative therapeutic strategies in cancer care.
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9
Selenium's potential in prostate cancer
Enhancing Radiotherapy Sensitivity in Prostate Cancer with Lentinan-Functionalized Selenium Nanoparticles: Mechanistic Insights and Therapeutic Potential.
Moderate impact on treatment assessment
We sought to understand how selenium, specifically in the form of lentinan-functionalized selenium nanoparticles (LET-SeNPs), can improve radiotherapy outcomes for prostate cancer. Our investigation showed that when these nanoparticles were combined with X-ray therapy, they significantly hampered the growth of prostate cancer cells and their ability to form colonies. This effect was greater than either treatment alone.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
The mechanism behind this enhanced sensitivity involved a complex interplay of cellular pathways. We observed that LET-SeNPs helped induce more robust apoptosis, or programmed cell death, by targeting various signaling routes in the cancer cells, such as the p53, MAPK, and AKT pathways. Moreover, they elevated levels of reactive oxygen species (ROS), which are known to promote apoptosis, while also decreasing the expression of Thioredoxin reductase, an enzyme that aids in DNA repair.
In animal models, the combination therapy proved effective in slowing down tumor growth, reinforcing our findings from the lab. These results suggest that using LET-SeNPs alongside X-ray therapy could potentially transform prostate cancer treatment, enhancing its effectiveness while possibly reducing side effects. Overall, we believe that selenium-modified nanoparticles hold significant promise for advancing cancer therapies.
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9
Prodrug enhances prostate cancer therapy
A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy.
Highly relevant to prostate cancer research
We explored an innovative approach to treating prostate cancer by developing a unique prodrug that combines a potent HDAC inhibitor with selenium. This new compound, known as SeSA-DCA, was designed to effectively target cancer cells while minimizing side effects.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
The study assessed how SeSA-DCA works in the body and its impact on various prostate cancer cell lines. We observed that this compound not only inhibited cancer cell growth but also prompted cell death and reduced metastasis significantly. Our animal studies revealed that SeSA-DCA led to notable tumor shrinkage without causing serious toxicity, outperforming even the standard treatment of docetaxel.
Additionally, we found that SeSA-DCA was stable in the body's environment and broke down rapidly in the tumor area, releasing its active components. This dual-action mechanism makes SeSA-DCA a promising candidate for prostate cancer therapy, potentially improving outcomes for patients while offering a safer alternative to traditional treatments. Overall, our findings suggest that selenium combined with HDAC inhibition can play a crucial role in advancing prostate cancer treatment strategies.
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9
Selenium's role in prostate cancer
Effects of natural extract interventions in prostate cancer: A systematic review and network meta-analysis.
Effectiveness tied to silybin
We conducted a systematic exploration of natural extracts, with a particular focus on selenium, and its role in managing prostate cancer. The available evidence includes findings from various studies, including our analysis, which assessed the effectiveness of selenium alone and in combination with other extracts, such as silybin.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
While selenium was noted in our findings, we found that its effectiveness is not straightforward. Specifically, the interaction between selenium and silybin complicated our ability to isolate the impact of selenium on its own. Thus, it became clear that, although some benefits arise from its combined use, we couldn’t definitively conclude that selenium alone delivers significant advantages for prostate cancer treatment.
Overall, the insights from our network meta-analysis suggest that while silybin and selenium together show promise, we need more studies to establish the detailed benefits and safety of selenium as a standalone treatment for prostate cancer. Those considering natural extract options should proceed with caution, keeping in mind the current limitations in evidence.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Cancer reduction
Essential. Since I started taking this supplement a few years ago, I no longer contract colds and flu. This supplement contains 100 mcg of Selenium per dosage (2 pills). Selenium could be beneficial, but it’s crucial not to overdose. A study showed that daily 200 micrograms of selenium reduced cancer occurrences by 42% among older participants compared to a placebo. Selenium users also had up to 63% fewer prostate cancers.
Read More
